The catalytic activitiy of highly dispersed metal nanoparticles in functionalized mesoporous silica SBA-15 prepared by a solution technique is demonstrated. The surface of SBA-15 was functionalized with positively charged groups, and anionic metal species were subsequently incorporated into the channel system via ion exchange. The anionic metal precursors were then reduced by either H-2 flow or by NaBH4 solution. Among the as-synthesized Au catalysts, two of them show activity for CO oxidation at room temperature. The most active Au catalyst was found to catalyse the reaction with a rate of 2.7x10(-4) mmol g(cat)(-1) s(-1), which is more active than any other silica-supported system made by a solution technique. On the other hand, supported Pd and Pd-Au nanoparticles in SBA-15 show capabilities as catalysts for Heck reactions. Buchwald-Hartwig-aminations and Suzuki-reactions are catalysed as well, but the yields, turnover-numbers (TONs) and turn-over-frequencies (TOFs) in these transformations are substantially lower than those of standard solution phase systems.