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    National Tsing Hua University Institutional Repository > 理學院 > 化學系 > 專利  >  Inhibitors of E-, P- and L-selectin binding


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/58164


    Title: Inhibitors of E-, P- and L-selectin binding
    Authors: Wong, Chi-Huey;Moris-Varas, Francisco;Lin, Chun-Cheng
    教師: 林俊成
    Date: 1998/11/3
    Relation: 專利權人:The Scripps Research Institute
    Keywords: blocking neutrophil inflamatory conditions
    binding assay
    aldolase
    derivative thereof
    dihydroxyacetone phosphate
    precursor
    aldol addition reaction
    glycoside
    aldehyde
    L-selectin binding
    Abstract: Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit an activity comparable to sialyl Lewis X with respect to the E-selectin binding assay and high activities in the P- and L-selectin binding assays. The inhibitors are employable for blocking neutrophil inflamatory conditions.
    URI: http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=6&f=G&l=50&co1=AND&d=PTXT&s1=5830871&OS=5830871&RS=5830871
    http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=US5830871&F=0
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/58164
    Appears in Collections:[化學系] 專利

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