National Tsing Hua University Institutional Repository:Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
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    NTHUR > College of Life Sciences  > Life Sciences > LIFE Journal / Magazine Articles  >  Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity

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    Title: Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
    Authors: Hung-Ju Shih;Hsiao-Huei Chen;Yen-An Chen;Meng-Hsun Wu;Gan-Guang Liou;Wei-Wen Chang;Linyi Chen;Lu-Hai Wang;Hsin-Ling Hsu
    Teacher: 陳令儀
    Date: 2012
    Publisher: Impact Journals LLC
    Relation: Oncotarget, Impact Journals LLC, Volume 3, No 11, NOV 2012, Pages 1401-1415
    Keywords: MCT-1
    Abstract: Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc gene in human carcinomas. The knockdown of MCT-1 enhances apoptotic cell death accompanied with the activation of caspases and cleavage of caspase substrates under environmental stress. The cancer cell proliferation, chemo-resistance and tumorigenic capacity are proved to be effectively suppressed by targeting MCT-1. Accordingly, an important linkage between MCT-1 oncogenicity and Shc pathway in tumor development has now been established. Promoting MCT-1 expression by gene hyperactivation may be recognized as a tumor marker and MCT-1 may serve as a molecular target of cancer therapy.
    Relation Link:[]=688
    Appears in Collections:[ Life Sciences] LIFE Journal / Magazine Articles
    [Institute of Molecular Medicine ] MMLIFE Journal / Magazine Articles
    [Brain Research Center] BRC Journal / Magazine Articles

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