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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Transcranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopy


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83596


    Title: Transcranial imaging of functional cerebral hemodynamic changes in single blood vessels using in vivo photoacoustic microscopy
    Authors: L.-D. Liao;C.-T. Lin;Y.-Y. I. Shih;T. Q. Duong;H.-Y. Lai;P.-H. Wang;R. Wu;S. Tsang;J.-Y. Chang;Meng-Lin Li;Y.-Y. Chen
    教師: 李夢麟
    Date: 2012
    Publisher: Nature Publishing Group
    Relation: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Nature Publishing Group, Volume 32, Issue 6, JUN 2012, Pages 938-951
    Keywords: DIFFUSE OPTICAL TOMOGRAPHY
    RAT FOREPAW STIMULATION
    ELECTRICAL-STIMULATION
    HIGH-RESOLUTION
    BRAIN
    FMRI
    DYNAMICS
    FLOW
    OXYGENATION
    CORTEX
    Abstract: Optical imaging of changes in total hemoglobin concentration (HbT), cerebral blood volume (CBV), and hemoglobin oxygen saturation (SO2) provides a means to investigate brain hemodynamic regulation. However, high-resolution transcranial imaging remains challenging. In this study, we applied a novel functional photoacoustic microscopy technique to probe the responses of single cortical vessels to left forepaw electrical stimulation in mice with intact skulls. Functional changes in HbT, CBV, and SO2 in the superior sagittal sinus and different-sized arterioles from the anterior cerebral artery system were bilaterally imaged with unambiguous 36x65-mu m(2) spatial resolution. In addition, an early decrease of SO2 in single blood vessels during activation (i.e., 'the initial dip') was observed. Our results indicate that the initial dip occurred specifically in small arterioles of activated regions but not in large veins. This technique complements other existing imaging approaches for the investigation of the hemodynamic responses in single cerebral blood vessels.
    Relation Link: http://www.nature.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83596
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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