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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model. Biomed


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83600


    Title: In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model. Biomed
    Authors: P.-H. Wang;J.-J. Luh;W.-S. Chen;Meng-Lin Li
    教師: 李夢麟
    Date: 2011
    Publisher: Optical Society of America
    Relation: BIOMEDICAL OPTICS EXPRESS, Optical Society of America, Volume 2, Issue 6, JUN 1 2011, Pages 1462-1469
    Keywords: HIGH-FREQUENCY ULTRASOUND
    COLOR DOPPLER ULTRASOUND
    NEOVASCULARIZATION
    MICROSCOPY
    TENDINOPATHY
    TENDINOSIS
    Abstract: Since neovascularization has been reported that it is associated with tendinopathy, assessments of vascularity are important for both diagnosis and treatment estimation. Photoacoustic imaging, taking the advantages of good ultrasonic resolution and high optical absorption contrast, has been shown a promising tool for vascular imaging. In this study, we explore the feasibility of photoacoustic micro-imaging in noninvasive monitoring of microvascular changes in Achilles tendon injuries on a mouse model in vivo. During collagenase-induced tendinitis, a 25-MHz photoacoustic microscope was used to image microvascular changes in Achilles tendons of mice longitudinally up to 23 days. In addition, complementary tissue structural information was revealed by collateral 25-MHz ultrasound microscopy. Morphological changes and proliferation of new blood vessels in Achilles tendons were observed during and after the acute inflammation. Observed microvascular changes during tendinitis were similar to the findings in the literatures. This study demonstrates that photoacoustic imaging can potentially be a complementary tool for high sensitive diagnosis and assessment of treatment performance in tendinopathy.
    Relation Link: http://www.osa.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83600
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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