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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83602


    Title: Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy
    Authors: Hung-Wei Yang;Hao-Li Liu;Meng-Lin Li;I-Wen Hsi;Chih-Tai Fan;Chiung-Yin Huang;Yu-Jen Lu;Mu-Yi Hua;Hsin-Yi Chou;Jiunn-Woei Liaw;Chen-Chi M. Ma;Kuo-Chen Wei
    教師: 李夢麟
    Date: 2013
    Publisher: Elsevier
    Relation: Biomaterials, Elsevier, Volume 34, Issue 22, July 2013, Pages 5651–5660
    Keywords: Magnetic gold nanorods
    Photoacoustic microscopy
    MRI
    Photothermal therapy
    Brain tumor
    Abstract: Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy.
    Relation Link: http://www.elsevier.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83602
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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