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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Neurovascular coupling: in vivo optical techniques for functional brain imaging


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83603


    Title: Neurovascular coupling: in vivo optical techniques for functional brain imaging
    Authors: Lun-De Liao;Vassiliy Tsytsarev;Ignacio Delgado-Martínez;Meng-Lin Li;Reha Erzurumlu;Ashwati Vipin;Josue Orellana;Yan-Ren Lin;Hsin-Yi Lai;You-Yin Chen;Nitish V Thakor
    教師: 李夢麟
    Date: 2013
    Publisher: BioMed Central
    Relation: BioMedical Engineering OnLine, BioMed Central, Volume 12, Issue 38, April 2013, Pages 1-20
    Keywords: Neurovascular coupling
    Cerebral neuroimaging
    2-photon microscopy
    Laser speckle contrast imaging
    Voltage sensitive dye imaging
    Functional photoacoustic microscopy
    Functional near-infrared spectroscopy
    Abstract: Optical imaging techniques reflect different biochemical processes in the brain, which is closely related with neural activity. Scientists and clinicians employ a variety of optical imaging technologies to visualize and study the relationship between neurons, glial cells and blood vessels. In this paper, we present an overview of the current optical approaches used for the in vivo imaging of neurovascular coupling events in small animal models. These techniques include 2-photon microscopy, laser speckle contrast imaging (LSCI), voltage-sensitive dye imaging (VSDi), functional photoacoustic microscopy (fPAM), functional near-infrared spectroscopy imaging (fNIRS) and multimodal imaging techniques. The basic principles of each technique are described in detail, followed by examples of current applications from cutting-edge studies of cerebral neurovascular coupling functions and metabolic. Moreover, we provide a glimpse of the possible ways in which these techniques might be translated to human studies for clinical investigations of pathophysiology and disease. In vivo optical imaging techniques continue to expand and evolve, allowing us to discover fundamental basis of neurovascular coupling roles in cerebral physiology and pathophysiology.
    Relation Link: http://www.biomedcentral.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83603
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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