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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 資訊工程學系 > 期刊論文 >  Constrained Multiple Sequence Alignment Tool Development and Its Application to RNase Family Alignment


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/12743


    Title: Constrained Multiple Sequence Alignment Tool Development and Its Application to RNase Family Alignment
    Authors: Tang,Chuan Yi
    Lu,Chin Lung
    Chang, M.D.-T.
    Tsai,Yin-Te
    Sun,Yuh-Ju
    Chao,Kun-Mao
    Chang,Jia-Ming
    Chiou,Yu-Han
    Wu,Chia-Mao
    Chang,Hao-Teng
    Chou,Wei-I
    Date: 2003
    Publisher: Institute of Electrical and Electronics Engineers Inc
    Keywords: biology computing
    computational complexity
    molecular biophysics
    Abstract: In this paper, we design an algorithm of computing a constrained multiple sequence alignment (CMSA) for guaranteeing that the generated alignment satisfies the user-specified constraints that some particular residues should be aligned together If the number of residues needed to be aligned together is a constant a, then the time-complexity of our CMSA algorithm for aligning K sequences is /spl Oscr/(/spl alpha/Kn/sup 4/), where n is the maximum of the lengths of sequences. In addition, we have build up such a CMSA software system and made several experiments on the RNase sequences, which mainly function in catalyzing the degradation of RNA molecules. The resulting alignments illustrate the practicability of our method.
    Relation Link: http://webservices.ieee.org/pindex_basic.html
    URI: http://nthur.lib.nthu.edu.tw/handle/987654321/12743
    Appears in Collections:[資訊工程學系] 期刊論文
    [資訊系統與應用研究所] 期刊論文
    [電腦與通訊科技研發中心] 期刊論文

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