National Tsing Hua University Institutional Repository:Constrained multiple sequence alignment tool development and its application to RNase family alignment
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    NTHUR > College of Electrical Engineering and Computer Science > Department of Computer Science > CS Conference Papers >  Constrained multiple sequence alignment tool development and its application to RNase family alignment


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/13918


    Title: Constrained multiple sequence alignment tool development and its application to RNase family alignment
    Authors: Chuan Yi Tang
    Chin Lung Lu
    Chang, M.D.-T.
    Yin-Te Tsai
    Yuh-Ju Sun
    Kun-Mao Chao
    Jia-Ming Chang
    Yu-Han Chiou
    Chia-Mao Wu
    Hao-Teng Chang
    Wei-I Chou
    Date: 2002
    Publisher: Institute of Electrical and Electronics Engineers Inc
    Keywords: constrained multiple sequence alignment
    RNA
    RNase sequences
    Abstract: In this paper, we design an algorithm of computing a constrained multiple sequence alignment (CMSA) for guaranteeing that the generated alignment satisfies the user-specified constraints that some particular residues should be aligned together If the number of residues needed to be aligned together is a constant a, then the time-complexity of our CMSA algorithm for aligning K sequences is /spl Oscr/(/spl alpha/Kn/sup 4/), where n is the maximum of the lengths of sequences. In addition, we have build up such a CMSA software system and made several experiments on the RNase sequences, which mainly function in catalyzing the degradation of RNA molecules. The resulting alignments illustrate the practicability of our method.
    Relation Link: http://webservices.ieee.org/pindex_basic.html
    URI: http://nthur.lib.nthu.edu.tw/handle/987654321/13918
    Appears in Collections:[Department of Computer Science] CS Conference Papers
    [Institute of Information Systems and Applications] ISA Conference Papers
    [Computer and Communication Research Center ] CCRC Conference Papers
    [Brain Research Center] BRC Conference Papers

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