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    National Tsing Hua University Institutional Repository > 工學院  > 化學工程學系 > 期刊論文 >  Anti-HCV activities of selective polyunsaturated fatty acidsq

    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/38276

    Title: Anti-HCV activities of selective polyunsaturated fatty acidsq
    Authors: Guang-Zhou Leu;Tiao-Yin Lin;John T.A. Hsu
    教師: 徐祖安
    Date: 2004
    Publisher: Elsevier
    Relation: Biochemical and Biophysical Research Communications, Elsevier, Volume 318, Issue 1, 21 May 2004, Pages 275-280
    Keywords: HCV
    Polyunsaturated fatty acids including arachidonic acid
    Eicosapentaenoic acid
    Docosahexaenoic acid
    Abstract: ©2004 Elsevier - HCV infection can lead to chronic infectious hepatitis disease with serious sequelae. Interferon-α, or its PEGylated form, plus ribavirin is the only treatment option to combat HCV. Alternative and more effective therapy is needed due to the severe side effects and unsatisfactory curing rate of the current therapy. In this study, we found that several polyunsaturated fatty acids (PUFAs) including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) are able to exert anti-HCV activities using an HCV subgenomic RNA replicon system. The EC50 (50% effective concentration to inhibit HCV replication) of AA was 4 μM that falls in the range of physiologically relevant concentration. At 100 μM, α-linolenic acid, γ-linolenic, and linoleic acid only reduced HCV RNA levels slightly and saturated fatty acids including oleic acid, myristic acid, palmitic acid, and steric acid had no inhibitory activities toward HCV replication. When AA was combined with IFN-α, strong synergistic anti-HCV effect was observed as revealed by an isobologram analysis. It will be important to determine whether PUFAs can provide synergistic antiviral effects when given as food supplements during IFN-based anti-HCV therapy. Further elucidation of the exact anti-HCV mechanism caused by AA, DHA, and EPA may lead to the development of agents with potent activity against HCV or related viruses.
    URI: http://www.elsevier.com/
    Appears in Collections:[化學工程學系] 期刊論文

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