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    National Tsing Hua University Institutional Repository > 工學院  > 化學工程學系 > 期刊論文 >  Core-shell type of nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] copolymers for drug delivery application: Synthesis, characterization and in vitro degradation


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/38341


    Title: Core-shell type of nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] copolymers for drug delivery application: Synthesis, characterization and in vitro degradation
    Authors: Huang CY (Huang, Chi-Yu);Lee YD (Lee, Yu-Der)
    教師: 李育德
    Date: 2006
    Publisher: Elsevier
    Relation: International Journal of Pharmaceutics, Elsevier, Volume 325, Issue 1-2, 15 November 2006, Pages 132-139
    Keywords: N-BUTYL CYANOACRYLATE
    ALKYL CHAIN-LENGTH
    PHYSICOCHEMICAL CHARACTERIZATION
    CARRIERS
    POLYMERIZATION
    NANOCAPSULES
    EMULSION
    ALPHA-CYANOACRYLATES)
    MICROSPHERES
    CYTOTOXICITY
    Abstract: ©2006 Elsevier - Core-shell type of nanoparticles (NPs) with manipulated degradation rate and balanced hydrophilic/hydrophobic properties were designed and characterized. The NPs based on the copolymers of n-butyl cyanoacrylate (BCA) and 2-octyl cyanoacrylate (OCA) were prepared by anion emulsion polymerization in 0.01N HCl solution with pluronic F127 as the stabilizer. These NPs were spherical in shape and with size smaller than 100 nm in a narrow distribution. The particle size, zeta potential, molecular weight, hydrophobicity and degradation rate of the copolymer depended on its composition significantly. In vitro chemical hydrolytic studies indicated that the degradation rate of the NPs could be controlled over 200-fold by adjusting the BCA/OCA ratio. Differential scanning calorimetry (DSC) measurements verified the existence of copolymer with tapered structure which was induced by the reactivity difference of the monomers. A BCA/OCA core-shell structure is postulated that the OCA rich segments were mainly located in the core of the NPs. The cytotoxicity of poly(2-octyl cyanoactylate) (POCA) is quite lower than that of poly(n-butyl cyanoacrylate) (PBCA) and the toxicity of poly(BCA-co-OCA) NPs is similar to that of PBCA NPs. (c) 2006 Elsevier B.V. All rights reserved.
    URI: http://www.elsevier.com/
    http://nthur.lib.nthu.edu.tw/handle/987654321/38341
    Appears in Collections:[化學工程學系] 期刊論文

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