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    National Tsing Hua University Institutional Repository > 原子科學院  > 工程與系統科學系 > 會議論文  >  A novel protein micro stamper with back-filling reservoir for simultaneous immobilization of large protein arrays

    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/47167

    Title: A novel protein micro stamper with back-filling reservoir for simultaneous immobilization of large protein arrays
    Authors: Shih-Chang Lin;Cheng-En Ho;Fan-Gang Tseng;Yi-Chin Tsai;Haimei Huang;Ching-Chang Chieng
    教師: 曾繁根
    Date: 2003
    Publisher: Institute of Electrical and Electronics Engineers
    Relation: Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE The Sixteenth Annual International Conference on, 19-23 Jan. 2003, Pages 299 - 302
    Keywords: back-filling
    Abstract: This paper proposes a novel stamping system using a back-filling micro-stamp chip with discrete dispensing channels to produce precise and uniform protein microarrays for disease diagnosis or drug screening. Unlike the micro arrayer spotting biosamples in serial, this novel device can simultaneously spot hundreds to thousands of bioreagents into a dense array in one minute. Reservoir filling, solution transportation, micro/nano imprinting, and droplet break-down processes of the micro stamp system employ only surface tension passively by the channel design of the device, thus no actuation means or external energy sources were required to manipulate bioreagents. Both simulation and experiment showed the capability of this system to accurately transfer proteins onto uniform arrays. Experimental results also verified that the spot size and intensity variations of spotted protein arrays were less than 5% across the whole chip with 144 protein spots
    URI: http://www.ieee.org/
    Appears in Collections:[工程與系統科學系] 會議論文

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