National Tsing Hua University Institutional Repository:Binding efficiency improvement of antibody to antigen on mixed self-assembly monolayers
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    National Tsing Hua University Institutional Repository > 原子科學院  > 工程與系統科學系 > 會議論文  >  Binding efficiency improvement of antibody to antigen on mixed self-assembly monolayers


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    题名: Binding efficiency improvement of antibody to antigen on mixed self-assembly monolayers
    作者: Chun-Lung Wu;Yu-Wen Lin;Yi-Lin Hsu;Fan-Gang Tseng;Ching-Chang Chieng
    教師: 錢景常
    日期: 2005
    出版者: Nano Science and Technology Institute
    關聯: 2005 NSTI Nanotechnology Conference and Trade Show. NSTI Nanotech 2005, 2005, p 359-62
    关键词: atomic force microscopy
    biochemistry
    biotechnology
    molecular biophysics
    molecular orientation
    monolayers
    nanopatterning
    proteins
    self-assembly
    surface plasmon resonance
    摘要: Protein chip is a potential tool on advanced disease diagnosis and drug screening, due to the capabilities of parallel process and trace-amount sample detection. The detection of proteins mainly depends on immune recognition, very sensitive to the orientation of immobilized proteins on solid surface. However, due to close packing of immobilized proteins on SAMs, the binding efficiency is usually lower than 10%. This paper proposed a novel way by employing mixed SAMs to generate nano patterns for effective separation of immobilized proteins to allow antibody conjugation from more directions. Testing results by Surface Plasma Resonance (SPR) and Atomic Force Microscope (AFM) investigation demonstrated a almost 3 fold increment on binding efficiency of protein immobilization on mixed SAMs
    URI: http://www.nsti.org/BioNano2005/showabstract.html?absno=1166
    http://www.nsti.org/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/47200
    显示于类别:[工程與系統科學系] 會議論文

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