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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  HUMAN PLASMA ENHANCES THE INFECTIVITY OF PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND MONOCYTE-DERIVED MACROPHAGES


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/48426


    Title: HUMAN PLASMA ENHANCES THE INFECTIVITY OF PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND MONOCYTE-DERIVED MACROPHAGES
    Authors: WU, SC;SPOUGE, JL;CONLEY, SR;TSAI, WP;MERGES, MJ;NARA, PL
    教師: 吳夙欽
    Date: 1995
    Publisher: American Society for Microbiology
    Relation: JOURNAL OF VIROLOGY,American Society for Microbiology,Volume 69,Issue 10,OCT 1995,Pages 6054-6062
    Keywords: T-CELLS
    CD4+ CELLS
    HIV
    ENTRY
    RECEPTOR
    REPLICATION
    Abstract: Physiological microenvironments such as blood, seminal plasma, mucosal secretions, or lymphatic fluids may influence the biology of the virus-host cell and immune interactions for human immunodeficiency virus type 1 (HIV-1). Relative to media, physiological levels of human plasma were found to enhance the infectivity of HIV-1 primary isolates in both phytohemagglutinin-stimulated peripheral blood mononuclear cells and monocyte-derived macrophages. Enhancement was observed only when plasma was present during the virus cell incubation and resulted in a 3- to 30-fold increase in virus titers in all of the four primary isolates tested, Both infectivity and virion binding experiments demonstrated a slow, time-dependent process generally requiring between 1 and 10 h. Human plasma collected in anticoagulants CPDA-1 and heparin, but not EDTA, exhibited this effect at concentrations from 90 to 40%. Furthermore, heat-inactivated plasma resulted in a loss of enhancement in peripheral blood mononuclear cells but not in monocyte-derived macrophages. Physiological concentrations of human plasma appear to recruit additional infectivity, thus increasing the infectious potential of the virus inoculum.
    URI: http://jvi.asm.org/cgi/content/abstract/69/10/6054
    http://www.asm.org/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/48426
    Appears in Collections:[生命科學系] 期刊論文

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