National Tsing Hua University Institutional Repository:Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein
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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein


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    题名: Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein
    作者: Lai, CW;Chan, ZR;Yang, DG;Lo, WH;Lai, YK;Chang, MDT;Hu, YC
    教師: 張大慈
    日期: 2006
    出版者: Elsevier
    關聯: FEBS Letters,Elsevier,Volume 580,Issue 16,10 July 2006,Pages 3829-3834
    关键词: apoptosis
    baculovirus
    insect cell
    membrane protein
    SARS-CoV
    摘要: It has been shown that severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3a and 7a proteins, but not membrane (M) protein, induce apoptosis in mammalian cells. Upon expression of SARS-CoV M protein using the baculovirus/insect cell expression system, however, we found that the expressed M protein triggered accelerated apoptosis in insect cells, as characterized by rapid cell death, elevated cytotoxicity, cell shrinkage, nuclear condensation and DNA fragmentation. Conversely, the M protein expressed in mammalian cells did not induce apoptosis. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed.
    URI: http://www.elsevier.com/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/48903
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