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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49309


    Title: Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis
    Authors: Lin TY;Huang CH;Kao HH;Liou GG;Yeh SR;Cheng CM;Chen MH;Pan RL;Juang JL
    教師: 葉世榮
    Date: 2009
    Publisher: Company of Biologists
    Relation: DEVELOPMENT,Company of Biologists,Volume 136,Issue 18,SEP 15 2009,Pages 3099-3107
    Keywords: ABELSON TYROSINE KINASE
    GROWTH CONE MOTILITY
    SYNAPTIC GROWTH
    Abstract: Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics. Abelson interacting protein (Abi), originally identified as a kinase substrate of Abl, also plays a key role in actin dynamics, yet its role with respect to Abl in the developing nervous system remains unclear. Here we show that mutations in abi disrupt axonal patterning in the developing Drosophila central nervous system (CNS). However, reducing abi gene dosage by half substantially rescues Abl mutant phenotypes in pupal lethality, axonal guidance defects and locomotion deficits. Moreover, we show that mutations in Abl increase synaptic growth and spontaneous synaptic transmission frequency at the neuromuscular junction. Double heterozygosity for abi and enabled (ena) also suppresses the synaptic overgrowth phenotypes of Abl mutants, suggesting that Abi acts cooperatively with Ena to antagonize Abl function in synaptogenesis. Intriguingly, overexpressing Abi or Ena alone in cultured cells dramatically redistributed peripheral F-actin to the cytoplasm, with aggregates colocalizing with Abi and/or Ena, and resulted in a reduction in neurite extension. However, co-expressing Abl with Abi or Ena redistributed cytoplasmic F-actin back to the cell periphery and restored bipolar cell morphology. These data suggest that abi and Abl have an antagonistic interaction in Drosophila axonogenesis and synaptogenesis, which possibly occurs through the modulation of F-actin reorganization.
    URI: http://www.biologists.com/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49309
    Appears in Collections:[生命科學系] 期刊論文

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