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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49395


    Title: Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein
    Authors: Lai, Chia-Wei;Chan, Zun-Ren;Yang, Ding-Gang;Lo, Wen-Hsin;Lai, Yiu-Kay;Chang, Margaret Dah-Tsyr;Hu, Yu-Chen
    教師: 黎耀基
    Date: 2006
    Publisher: Elsevier
    Relation: FEBS Letters,Elsevier,Volume 580,Issue 16,10 July 2006,Pages 3829-3834
    Keywords: apoptosis
    baculovirus
    insect cell
    membrane protein
    SARS-CoV
    Abstract: It has been shown that severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3a and 7a proteins, but not membrane (M) protein, induce apoptosis in mammalian cells. Upon expression of SARS-CoV M protein using the baculovirus/insect cell expression system, however, we found that the expressed M protein triggered accelerated apoptosis in insect cells, as characterized by rapid cell death, elevated cytotoxicity, cell shrinkage, nuclear condensation and DNA fragmentation. Conversely, the M protein expressed in mammalian cells did not induce apoptosis. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed.
    URI: http://www.elsevier.com/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49395
    Appears in Collections:[生命科學系] 期刊論文

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