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    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49503


    Title: Charge effects in neurofilament networks
    Authors: Janmey PA;Wagner OI;Mullin C;Leterrier JF
    教師: 王歐力
    Date: 2004
    Publisher: American Chemical Society
    Relation: 228th ACS National Meeting,Philadelphia,PA,August 22-26,2004,Pages U485-U485
    Keywords: neurofilament
    Abstract: Neurofilaments are protein polymers localized to the cytoskeleton of neuronal cells and have physical characteristics that differentiate them from other biopolymers. Neurofilaments are approximately 15 nm in diameter and many microns long, with persistence length less than 1 micron. Extending away from the core of the filament are large unstructured polypeptides that have hydrodynamic diameters ranging from 50 to 110 nm, depending on their extent of phosphorylation. These unstructured sidearms have net charges ranging from near neutrality to -110 per Mr = 50,000. Changes in electrostatic charge alter the effective volume of these brush-like polymers, and interactions of the anionic polymers with polyvalent cations lead to aggregation and re-solubilization that appears to coincide with charge reversal of the polyelectrolyte filaments.
    URI: http://pubs.acs.org/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/49503
    Appears in Collections:[生命科學系] 會議論文

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