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    National Tsing Hua University Institutional Repository > 理學院 > 物理系 > 期刊論文 >  Generation of Magnetic Retroviral Vectors with Magnetic Nanoparticles


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/55964


    Title: Generation of Magnetic Retroviral Vectors with Magnetic Nanoparticles
    Authors: Ming-Fong Tai;Kai-Ming Chi;K.-H. William Lau;David Baylink;Shin-Tai Chen
    教師: 戴明鳳
    Date: 2003
    Publisher: Institute of Problems of Mechanical Engineering
    Relation: Rev. Adv. Mater. Sci., Advanced Study Center, Volume 5, 2003, Pages 319-323
    Keywords: magnetic nanoparticles
    gene transduction efficiency
    Abstract: We have successfully synthesized iron and gamma ferric oxide magnetic nanoparticleswith particle sizes of 4±0.8 nm through a high-yield chemical thermal reflux method.Polyethyleneimine (PEI) was used to enhance biologically compatibility and monodispersion ofnanoparticles. The PEI coated magnetic nanoparticles have sizes between 100 to 200 nm. Moreimportantly, we formed magnetic retroviral vectors through combining Moloney leukemia virusbased retroviral vectors with the particles. An external magnetic field can bring the magneticretroviral vectors to the targeted cells and significantly raised the gene transduction efficiency. Wepresent physical properties and biological activities of magnetic nanoparticles associated withretroviral vectors
    URI: http://www.ipme.ru/e-journals/RAMS/no_4503/tai/tai.pdf
    http://www.ipme.ru/e-journals/RAMS/
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/55964
    Appears in Collections:[物理系] 期刊論文

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