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    National Tsing Hua University Institutional Repository > 研究中心 > 奈微與材料科技中心 > 期刊論文 >  Carbon nanotubes as affinity probes for peptides and proteins in MALDI MS analysis


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/61655


    Title: Carbon nanotubes as affinity probes for peptides and proteins in MALDI MS analysis
    Authors: Chen WY;Wang LS;Chiu HT;Chen YC;Lee CY
    教師: 李紫原
    Date: 2004
    Publisher: Elsevier
    Relation: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,Volume: 15,Issue: 11,Pages: 1629-1635,Published: NOV 2004
    Keywords: DESORPTION/IONIZATION MASS-SPECTROMETRY
    LASER-DESORPTION/IONIZATION
    POROUS SILICON
    Abstract: Recently, carbon nanotubes (CNTs) have been reported to be an effective MALDI matrix for small molecules Anal. Chem 2003, 75, 6191). In a somewhat related study, we have employed CNTs produced by using NaH-treated anodic aluminum oxide (Na@AAO) as a reactive template as the assisting matrix for MALDI analysis upon the addition of high concentrations of citrate buffer. Our results indicate that the mass range can be extended to ca. 12,000 Da and that alkali metal adducts of analytes are effectively reduced. Furthermore, we have employed citric acid-treated CNTs as affinity probes to selectively concentrate traces of analytes from aqueous solutions. High concentrations of salts and surfactants in the sample solutions are also tolerated. This approach is very suitable for the MALDI analysis of small proteins, peptides, and protein enzymatic digest products.
    URI: http://www.elsevier.com/wps/find/homepage.cws_home
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/61655
    Appears in Collections:[奈微與材料科技中心] 期刊論文

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