This study discusses the wear resistance and high-temperature compression strength of CuCoNiCrAl0.5Fe alloy with various amounts of boron addition. Experiments show that within the atomic ratio of boron addition from x = 0 to x = 1.0 in CuCoNiCrAl0.5FeBx (referred to as B-0 to B-1.0 alloys), the alloys are of fcc structure with boride precipitation. The volume fraction of borides increases with increasing boron addition. The corresponding hardness increases from HV 232 to HV 736. Wear resistance and high-temperature compression strength are significantly enhanced by the formation of boride. The alloys with boride are less tough. The superior wear resistance of B-1.0 alloy, which is even better than SUJ2 wear-resistant steel, indicates that the CuCoNiCrAl0.5FeBx alloys have potential applications as ambient- and high-temperature mold, tool, and structural materials.