English  |  正體中文  |  简体中文  |  Items with full text/Total items : 54367/62174 (87%)
Visitors : 13949254      Online Users : 57
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTHU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy

    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/71588

    Title: Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy
    Authors: L.-D. Liao;M.-L. Li;H.-Y. Lai;Y.-Y. Shih;Y.-C. Lo;S. Tsang;P. C.-P. Chao;C.-T. Lin;F.-S. Jaw;Y.-Y. Chen
    教師: 李夢麟
    Date: 2010
    Publisher: Elsevier
    Relation: NeuroImage, Elsevier, Volume 52, Issue 2, Aug. 15 2010, Pages 562-570
    Keywords: Hemoglobin oxygen saturation (SO2)
    Total hemoglobin concentration (HbT)
    Functional photoacoustic microscopy (fPAM)
    Electrical stimulation
    Abstract: The present study reported the development of a novel functional photoacoustic microscopy (fPAM) system for investigating hemodynamic changes in rat cortical vessels associated with electrical forepaw stimulation. Imaging of blood optical absorption by fPAM at multiple appropriately-selected and distinct wavelengths can be used to probe changes in total hemoglobin concentration (HbT, i.e., cerebral blood volume [CBV]) and hemoglobin oxygen saturation (SO2). Changes in CBV were measured by images acquired at a wavelength of 570 nm (λ570), an isosbestic point of the molar extinction spectra of oxy- and deoxy-hemoglobin, whereas SO2 changes were sensed by pixel-wise normalization of images acquired at λ560 or λ600 to those at λ570. We demonstrated the capacity of the fPAM system to image and quantify significant contralateral changes in both SO2 and CBV driven by electrical forepaw stimulation. The fPAM system complements existing imaging techniques, with the potential to serve as a favorable tool for explicitly studying brain hemodynamics in animal models.
    Relation Link: http://www.elsevier.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/71588
    Appears in Collections:[電機工程學系] 期刊論文

    Files in This Item:

    File Description SizeFormat


    SFX Query


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback