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    National Tsing Hua University Institutional Repository > 原子科學院  > 生醫工程與環境科學系 > 會議論文  >  Evaluating the reproducibility and regional variation of wall shear stress in rat model with the use of flow-sensitive MRI


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/78781


    Title: Evaluating the reproducibility and regional variation of wall shear stress in rat model with the use of flow-sensitive MRI
    Authors: Peng, Shin-Lei;Peng, Hsu-Hsia;Yang, Tao-Chieh;Hsu, Jee-Ching;Wu, Yi-Chun;Wang, Fu-Nien
    Description: 清華大學學生國際會議獲獎論文:彭馨蕾
    Magna Cum Laude Award
    Date: 2012
    Publisher: International Society for Magnetic Resonance in Medicine
    Relation: Annual Meeting of International Society for Magnetic Resonance in Medicine, ISMRM, Utah, USA, Apr. 2013, Pages 1330
    Keywords: MRI
    wall shear stress
    atherosclerosis
    Abstract: With advantages of non-invasive, phase-contrast magnetic resonance imaging (PC-MRI) is valuable by providing information regarding the
    assessment of blood flow. The measurement of local flow profiles provide insights into the blood rheology, gaining the flow velocity and its derived
    parameters, such as wall shear stress (WSS) [1]. It has been proposed that exposure of the arterial wall to a relatively lower WSS will contribute to
    the development of atherosclerosis [2]. Rats with native hypertension (spontaneously hypertensive rat, SHR) are an excellent animal model to go
    further study on the atherosclerosis. However, WSS derived from PC-MRI in SHR model has not been fully discussed. This may be due partly to the
    fact that less numbers of image pixels covering the vessel lumen may contribute to errors in velocity estimation [3]. In this study, we concentrated on
    exploring the hemodynamic patterns of common carotid arteries (CCA) in the SHR model by measuring WSS with PC-MRI. The reproducibility of
    measured WSS was investigated to evaluate the errors resulted from limited numbers of pixels within the lumen of CCA. In addition, regional
    variations of WSS at each vascular segment were also computed to show the regional abnormal WSS in SHR model.
    URI: http://submissions.miracd.com/ismrm2013/proceedings/files/1330.PDF
    http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/78781
    http://www.ismrm.org/
    Appears in Collections:[生醫工程與環境科學系] 會議論文

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