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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Elephantopus scaber Inhibits Lipopolysaccharide-Induced Liver Injury by Suppression of Signaling Pathways in Rats


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81426


    Title: Elephantopus scaber Inhibits Lipopolysaccharide-Induced Liver Injury by Suppression of Signaling Pathways in Rats
    Authors: Hsiao-Fang Hung;Chien-Wei Hou;Yi-Ling Chen;Chih-Cheng Lin;Hua-Wen Fu;Jen-Shu Wang;Kee-Ching Jeng
    教師: 傅化文
    Date: 2011
    Publisher: World Scientific Publishing
    Relation: American Journal of Chinese Medicine, World Scientific Publishing, Volume 39, Issue 4, 2011, Pages 705-717
    Keywords: Elephantopus scaber
    Anti-Inflammation
    p38 MAPK
    COX-2
    Abstract: Elephantopus scaber (ES, Teng-Khia-U) has been traditionally used for the treatment of nephritis, pain, and fever; however, the direct evidence is lacking. We investigated the effect of ES on lipopolysaccharide (LPS) induced inflammation of BV-2 microglial cells and acute liver injury in Sprague-Dawley (SD) rats. Our results showed that ES reduced LPS-induced nitric oxide (NO), interleukin (IL)-1, IL-6, reactive oxygen species
    (ROS), and prostaglandin (PGE2) production in BV-2 cells. ES significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats. Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats. Taken together, these results indicate that the protective mechanism of ES involves an antioxidant effect and inhibition of p38 MAP kinase and COX-2 expressions in LPS-stressed acute hepatic injury in SD rats.
    Relation Link: http://www.worldscinet.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81426
    Appears in Collections:[分子與細胞生物研究所] 期刊論文
    [生命科學系] 期刊論文

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