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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Helicobacter pylori neutrophil-activating protein: From molecular pathogenesis to clinical applications


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81437


    Title: Helicobacter pylori neutrophil-activating protein: From molecular pathogenesis to clinical applications
    Authors: Hua-Wen Fu
    教師: 傅化文
    Date: 2014
    Publisher: Baishideng Publishing Group
    Relation: World Journal of Gastroenterology, Baishideng Publishing Group, Volume 20, Issue 18, MAy 2014, pp.5294-5301
    Keywords: Helicobacter pylori
    Helicobacter pylori neutrophil-activating protein
    Clinical application
    Vaccine
    Diagnosis
    Drug development
    Immunotherapy
    Immunomodulation
    T helper cell type Ⅰ/Ⅱ
    Abstract: Helicobacter pylori (H. pylori ) neutrophil-activating protein (HP-NAP) was originally identified as a virulence factor of H. pylori for its ability to activate neutrophils to generate respiratory burst by releasing reactive oxygen species. Later on, HP-NAP was also found to be involved in the protection of H. pylori from DNA damage, supporting the survival of H. pylori under oxidative stress. This protein is highly conserved and expressed by virtually all clinical isolates of H. pylori . The majority of patients infected with H. pylori produced antibodies specific for HP-NAP, suggesting its important role in immunity. In addition to acting as a pathogenic factor by activating the innate immunity through a wide range of human leukocytes, including neutrophils, monocytes, and mast cells, HP-NAP also mediates adaptive immunity through the induction of T helper cell type Ⅰ responses. The pro-inflammatory and immunomodulatory properties of HP-NAP not only make it play an important role in disease pathogenesis but also make it a potential candidate for clinical use. Even though there is no convincing evidence to link HP-NAP to a disease outcome, recent findings supporting the pathogenic role of HP-NAP will be reviewed. In WJG 20th Anniversary Special Issues (6): Helicobacter pylori TOPIC HIGHLIGHT addition, the potential clinical applications of HP-NAP in vaccine development, clinical diagnosis, and drug development will be discussed.
    Relation Link: http://www.wjgnet.com/1007-9327/index.htm
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81437
    Appears in Collections:[分子與細胞生物研究所] 期刊論文
    [生命科學系] 期刊論文

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