English  |  正體中文  |  简体中文  |  Items with full text/Total items : 54367/62174 (87%)
Visitors : 10052991      Online Users : 138
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTHU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81439


    Title: Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury
    Authors: Yi-Wen Chen;Hsiu-Chuan Chou;Szu-Ting Lin;You-Hsuan Chen;Yu-Jung Chang;Linyi Chen;Hong-Lin Chan
    教師: 陳令儀
    Date: 2013
    Publisher: Hindawi Publishing Corporation
    Relation: Evidence-Based Complementary and Alternative Medicine, Hindawi Publishing Corporation, Volume 2013, Article ID 364519, 2013, 16 pages
    Keywords: OXIDATIVE STRESS
    CELL-DEATH
    MYOCARDIAL-ISCHEMIA
    SIGNAL TRANSDUCERS
    REPERFUSION INJURY
    CEREBRAL-ISCHEMIA
    TRANSCRIPTION 3
    MUSCLE-CELLS
    EXPRESSION
    ACTIVATION
    Abstract: Quercetin, a polyphenolic compound existing in many vegetables, fruits, has antiinflammatory, antiproliferation, and antioxidant effect on mammalian cells. Quercetin was evaluated for protecting cardiomyocytes from ischemia/reperfusion injury, but its protective mechanism remains unclear in the current study. The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression. Fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can reveal the differentially expressed proteins of H9C2 cells treated with H2O2 or quercetin. Although 17 identified proteins were altered in H2O2-induced cells, these proteins such as alpha-soluble NSF attachment protein (alpha-SNAP), Ena/VASP-like protein (Evl), and isopentenyl-diphosphate delta-isomerase 1 (Idi-1) were reverted by pretreatment with quercetin, which correlates with kinase activation, DNA repair, lipid, and protein metabolism. Quercetin dephosphorylates Src kinase in H2O2-induced H9C2 cells and likely blocks the H2O2-induced inflammatory response through STAT3 kinase modulation. This probably contributes to prevent ischemia/reperfusion injury in cardiomyocytes.
    Relation Link: http://www.hindawi.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81439
    Appears in Collections:[腦科學研究中心] 期刊論文
    [分子醫學研究所] 期刊論文
    [生命科學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    2050132010014.pdf4842KbAdobe PDF701View/Open


    在NTHUR中所有的資料項目都受到原著作權保護,僅提供學術研究及教育使用,敬請尊重著作權人之權益。若須利用於商業或營利,請先取得著作權人授權。
    若發現本網站收錄之內容有侵害著作權人權益之情事,請權利人通知本網站管理者(smluo@lib.nthu.edu.tw),管理者將立即採取移除該內容等補救措施。

    SFX Query

    與系統管理員聯絡

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback