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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81441


    Title: Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
    Authors: Hung-Ju Shih;Hsiao-Huei Chen;Yen-An Chen;Meng-Hsun Wu;Gan-Guang Liou;Wei-Wen Chang;Linyi Chen;Lu-Hai Wang;Hsin-Ling Hsu
    教師: 陳令儀
    Date: 2012
    Publisher: Impact Journals LLC
    Relation: Oncotarget, Impact Journals LLC, Volume 3, No 11, NOV 2012, Pages 1401-1415
    Keywords: MCT-1
    Shc
    Ras
    ERK
    apoptosis
    tumor
    Abstract: Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc gene in human carcinomas. The knockdown of MCT-1 enhances apoptotic cell death accompanied with the activation of caspases and cleavage of caspase substrates under environmental stress. The cancer cell proliferation, chemo-resistance and tumorigenic capacity are proved to be effectively suppressed by targeting MCT-1. Accordingly, an important linkage between MCT-1 oncogenicity and Shc pathway in tumor development has now been established. Promoting MCT-1 expression by gene hyperactivation may be recognized as a tumor marker and MCT-1 may serve as a molecular target of cancer therapy.
    Relation Link: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=688
    http://www.impactjournals.com/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81441
    Appears in Collections:[生命科學系] 期刊論文
    [分子醫學研究所] 期刊論文
    [腦科學研究中心] 期刊論文

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