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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  Interplay between Cell Migration and Neurite Outgrowth Determines SH2B1β-Enhanced Neurite Regeneration of Differentiated PC12 Cells


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81442


    Title: Interplay between Cell Migration and Neurite Outgrowth Determines SH2B1β-Enhanced Neurite Regeneration of Differentiated PC12 Cells
    Authors: Chia-Ling Wu;Yu-Han Chou;Yu-Jung Chang;Nan-Yuan Teng;Hsin-Ling Hsu;Linyi Chen
    教師: 陳令儀
    Date: 2012
    Publisher: Public Library of Science
    Relation: PLoS One, Public Library of Science, Volume 7, Issue 4, APR 2012, e34999.
    Keywords: PROTEIN-KINASE-C
    NERVE GROWTH-FACTOR
    HUMAN NEURODEGENERATIVE DISORDERS
    NEURONAL MIGRATION
    AXONAL-TRANSPORT
    MAP KINASE
    PHOSPHATIDYLINOSITOL-3 KINASE
    NEUROTROPHIC FACTORS
    SENSORY NEURONS
    BRAIN-INJURY
    Abstract: The regulation of neurite outgrowth is crucial in developing strategies to promote neurite regeneration after nerve injury
    and in degenerative diseases. In this study, we demonstrate that overexpression of an adaptor/scaffolding protein SH2B1b
    promotes neurite re-growth of differentiated PC12 cells, an established neuronal model, using wound healing (scraping)
    assays. Cell migration and the subsequent remodeling are crucial determinants during neurite regeneration. We provide
    evidence suggesting that overexpressing SH2B1β enhances protein kinase C (PKC)-dependent cell migration and
    phosphatidylinositol 3-kinase (PI3K)-AKT-, mitogen activated protein kinase (MAPK)/extracellular signal-regulated protein
    kinase (ERK) kinase (MEK)-ERK-dependent neurite re-growth. Our results further reveal a cross-talk between pathways
    involving PKC and ERK1/2 in regulating neurite re-growth and cell migration. We conclude that temporal regulation of cell
    migration and neurite outgrowth by SH2B1β contributes to the enhanced regeneration of differentiated PC12 cells.
    Relation Link: http://www.plos.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81442
    Appears in Collections:[生命科學系] 期刊論文
    [分子醫學研究所] 期刊論文
    [腦科學研究中心] 期刊論文

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