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    National Tsing Hua University Institutional Repository > 生命科學院  > 生命科學系 > 期刊論文 >  SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81446


    Title: SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation
    Authors: Tien-Cheng Wang;Yi-Hsuan Li;Kuan-Wei Chen;Ching-Jen Chen;Chia-Ling Wu;Nan-Yuan Teng;Linyi Chen
    教師: 陳令儀
    Date: 2011
    Publisher: Wiley-Blackwell
    Relation: Journal of Cellular Physiology, Wiley-Blackwell, Volume 226, Issue 8, APR 2011, Pages 2063-2074
    Keywords: BETA-CATENIN
    NEURONAL DIFFERENTIATION
    EXPRESSION
    SH2-B-BETA
    MOLECULES
    OUTGROWTH
    CLEAVAGE
    EMBRYOS
    SUBSET
    GENES
    Abstract: Little is known regarding the role of inter-cellular interaction during neuronal differentiation. Homophilic N-cadherin engagement
    between cells contributes to neuronal migration. However, its function in neurite initiation is not clear. In this study, we provide the first
    evidence that the adaptor protein SH2B1β regulated N-cadherin levels and neurite initiation. Overexpression of SH2B1β reduces
    N-cadherin levels and increased phosphotyrosine 654 β-catenin, leading to increased nerve growth factor-induced neurite initiation in
    PC12 cells, an established model for neuronal differentiation. In contrast, overexpression of the dominant-negative mutant
    SH2B1β(R555E) increases N-cadherin expression, cell-cell aggregation, and reduces neurite initiation. Moreover, SH2B1β binds directly
    or indirectly to N-cadherin indicative of its involvement in regulating the levels of N-cadherin. Taken together, these findings provide
    significant new insights into how N-cadherin-mediated inter-cellular interactions may influence neurite initiation and how SH2B1β may
    regulate these processes.
    Relation Link: http://www.wiley.com/wiley-blackwell‎
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/81446
    Appears in Collections:[生命科學系] 期刊論文
    [分子醫學研究所] 期刊論文
    [腦科學研究中心] 期刊論文

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