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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83595


    Title: Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy
    Authors: L.-D. Liao;C.-T. Lin;Y.-Y. I. Shih;H.-Y. Lai;W.-T. Zhao;T. Q. Duong;J.-Y. Chang;Y.-Y. Chen;Meng-Lin Li
    教師: 李夢麟
    Date: 2012
    Publisher: International Society for Optical Engineering
    Relation: JOURNAL OF BIOMEDICAL OPTICS, International Society for Optical Engineering, Volume 17, Issue 6, JUN 2012, Article Number 061210
    Keywords: DIFFUSE OPTICAL TOMOGRAPHY
    RAT FOREPAW STIMULATION
    ELECTRICAL-STIMULATION
    COMPUTED-TOMOGRAPHY
    BRAIN
    FLOW
    OXYGENATION
    RESOLUTION
    CORTEX
    VOLUME
    Abstract: The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate single cerebral blood vessels of rats after left forepaw stimulation. In this system, we analyzed the spatiotemporal evolution of the HRFs of the total hemoglobin concentration (HbT), cerebral blood volume (CBV), and hemoglobin oxygen saturation (SO2). Changes in specific cerebral vessels corresponding to various electrical stimulation intensities and durations were bilaterally imaged with 36 x 65-mu m(2) spatial resolution. Stimulation intensities of 1, 2, 6, and 10 mA were applied for periods of 5 or 15 s. Our results show that the relative functional changes in HbT, CBV, and SO2 are highly dependent not only on the intensity of the stimulation, but also on its duration. Additionally, the duration of the stimulation has a strong influence on the spatiotemporal characteristics of the HRF as shorter stimuli elicit responses only in the local vasculature (smaller arterioles), whereas longer stimuli lead to greater vascular supply and drainage. This study suggests that the current fPAM system is reliable for studying relative cerebral hemodynamic changes, as well as for offering new insights into the dynamics of functional cerebral hemodynamic changes in small animals.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83595
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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