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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83597


    Title: Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model
    Authors: P.-H. Wang;H.-L. Liu;P.-H. Hsu;C.-Y. Lin;C.-R. C. Wang;P.-Y. Chen;K.-C. Wei;T.-C. Yen;Meng-Lin Li
    教師: 李夢麟
    Date: 2012
    Publisher: International Society for Optical Engineering
    Relation: JOURNAL OF BIOMEDICAL OPTICS, International Society for Optical Engineering, Volume 17, Issue 6, JUN 2012, Article Number 061222
    Keywords: IN-VIVO
    MICROSCOPY
    DISRUPTION
    TOMOGRAPHY
    DELIVERY
    RABBITS
    GENE
    Abstract: In this study, we develop a novel photoacoustic imaging technique based on gold nanorods (AuNRs) for quantitatively monitoring focused-ultrasound (FUS) induced blood-brain barrier (BBB) opening in a rat model in vivo. This study takes advantage of the strong near-infrared absorption (peak at similar to 800 nm) of AuNRs and the extravasation tendency from BBB opening foci due to their nano-scale size to passively label the BBB disruption area. Experimental results show that AuNR contrast-enhanced photoacoustic microscopy (PAM) successfully reveals the spatial distribution and temporal response of BBB disruption area in the rat brains. The quantitative measurement of contrast enhancement has potential to estimate the local concentration of AuNRs and even the dosage of therapeutic molecules when AuNRs are further used as nano-carrier for drug delivery or photothermal therapy. The photoacoustic results also provide complementary information to MRI, being helpful to discover more details about FUS induced BBB opening in small animal models.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83597
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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