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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 期刊論文 >  Deep-penetration photoacoustic array imaging of calcifications


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83601


    Title: Deep-penetration photoacoustic array imaging of calcifications
    Authors: Tsai-Chu Hsiao;Yao-Yu Cheng;Wan-Ting Tein;Shih-Bin Luo;De-Yi Chiou;Ren-Jei Chung;Meng-Lin Li
    教師: 李夢麟
    Date: 2013
    Publisher: Society of Photo-optical Instrumentation Engineers
    Relation: Journal of Biomedical Optics, Society of Photo-optical Instrumentation Engineers, Volume 18, Issue 6, Jun. 03, 2013, 066002
    Abstract: Calcifications are one of the most important indicators for early breast cancer detection. We explore the feasibility of deep-penetration photoacoustic (PA) imaging of calcifications based on a medical ultrasound array imaging platform. Intralipid and chicken breast phantoms embedded with different-sized hydroxyapatite (HA) particles, which are the major components of calcifications, were imaged to verify the equipment’s capability and penetration depth for the visualization of calcifications. An optimal near-infrared excitation wavelength was selected to maximize PA signals of HAs, resulting in a better HA signal-to-blood ratio. We demonstrated that PA imaging is capable of visualizing 0.5-mm HA particles at a depth of 3 cm in chicken breast phantoms. The noise-equivalent penetration depth of the system for visualizing 0.5-mm HA particles in the human breast was estimated to be about 2.9 to 3.5 cm, which is clinically relevant as calcifications are usually found at a depth of 0.6 to 3.0 cm. Moreover, the feasibility of differentiating HA from blood by the PA spectroscopic technique was presented and the mechanism of the HA signal generation was discussed. The results show that PA imaging is a promising technique for real-time visualization of breast calcifications.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83601
    Appears in Collections:[電機工程學系] 期刊論文
    [光電研究中心] 期刊論文

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