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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 會議論文  >  Functional photoacoustic micro-imaging of rat cerebral hemodynamic response function in single vessels during forepaw electrical stimulation


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83947


    Title: Functional photoacoustic micro-imaging of rat cerebral hemodynamic response function in single vessels during forepaw electrical stimulation
    Authors: L.-D. Liao;Y.-Y. Chen;C.-T. Lin;J.-Y. Chang;M.-L. Li
    教師: 李夢麟
    Date: 2012
    Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
    Relation: Conference on Photons Plus Ultrasound - Imaging and Sensing/Photonics West BiOS Symposium, San Francisco, CA, JAN 22-24, 2012
    Keywords: BLOOD-FLOW
    COMPUTED-TOMOGRAPHY
    MICROSCOPY
    BRAIN
    OXYGENATION
    RESOLUTION
    Abstract: The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate the spatiotemporal evolution of the HRFs of hemoglobin concentration (HbT), cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO2) in single cerebral vessels to rat left-forepaw stimulation. The HRF changes in specific cerebral vessels responding to different stimulation intensities and durations were bilaterally imaged with 36 x 65-mu m spatial resolution. Various electrical stimulations were applied with stimulation intensities at 1, 2, 6 and 10-mA combined with 5-s and 15-s stimulation durations, respectively. Our main findings were as follows: 1) the functional HbT and SO2 increased sub-linearly with increasing stimulus intensities and 2) the results suggested that the CBV changes are more linearly correlated with arterioles than HbT and SO2 within a limited dynamic range of stimulation intensities and duration. The findings in this study indicate that the regulation of hemodynamic changes in single cerebral vessels can be reliable studied by the fPAM technique without the use of contrast agents.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83947
    Appears in Collections:[電機工程學系] 會議論文
    [光電研究中心] 會議論文

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