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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 會議論文  >  DVD pickup head based optical resolution photoacoustic microscopy

    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83948

    Title: DVD pickup head based optical resolution photoacoustic microscopy
    Authors: P.-H. Wang;M.-L. Li
    教師: 李夢麟
    Date: 2012
    Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
    Relation: Conference on Photons Plus Ultrasound - Imaging and Sensing/Photonics West BiOS Symposium, San Francisco, CA, JAN 22-24, 2012
    Keywords: photoacoustic microscopy
    DVD pickup head
    micro-vascular imaging
    Abstract: Optical resolution photoacoustic microscopy (OR-PAM) has been shown as a promising tool for label-free microvascular and single-cell imaging in clinical and bioscientific applications. However, most OR-PAM systems are realized by using a bulky laser for photoacoustic excitation. The large volume and high price of the laser may restrain the popularity of OR-PAM. In this study, we develop a low-cost and compact OR-PAM system based on a commercially available DVD pickup head. We showed that the DVD pickup head have the required laser energy and focusing optics for OR-PAM. The firmware of a DVD burner was modified to enable its laser diode to provide a 13-ns laser pulse with 1.3-nJ energy at 650 nm. Two excitation wavelengths at 650 and 780 nm were available. The laser beam was focused onto the target after passing through a 0.6-mm thick DVD transparent polycarbonate coating, and then aligned to be confocal with a 50-MHz focused ultrasonic transducer in forward mode. To keep the target on focus, a scan involving auto-tracking procedure was performed. The lateral resolution was verified via cross-sectional imaging of a 6-mu m carbon fiber. The measured -6 dB width of the carbon fiber was 6.66 mu m which was in agreement with optical diffraction limit. The proposed OR-PAM has potential as an economically viable and compact blood screening tool available outside of large laboratories due to its low cost and portability. Furthermore, a better spatial resolution could be provided by using a blue ray DVD pickup head.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83948
    Appears in Collections:[電機工程學系] 會議論文
    [光電研究中心] 會議論文

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