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    National Tsing Hua University Institutional Repository > 電機資訊學院 > 電機工程學系 > 會議論文  >  Functional transcranial photoacoustic micro-imaging of mouse cerebrovascular crosssection and hemoglobin oxygenation changes during forepaw electrical stimulation


    Please use this identifier to cite or link to this item: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83954


    Title: Functional transcranial photoacoustic micro-imaging of mouse cerebrovascular crosssection and hemoglobin oxygenation changes during forepaw electrical stimulation
    Authors: L.-D. Liao;Y.-Y. Chen;C.-T. Lin;J.-Y. Chang;M.-L. Li
    教師: 李夢麟
    Date: 2011
    Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
    Relation: Conference on Photons Plus Ultrasound - Imaging and Sensing, San Francisco, CA, JAN 23-25, 2011
    Keywords: Functional imaging
    photoacoustic microscopy
    electrical stimulation
    somatosensory cortex
    vasodilatation
    hemoglobin oxygenation
    Abstract: In this study, we report on using a 50-MHz functional photoacoustic microscopy (PAM) to transcranially image the cross-section and hemoglobin oxygenation (SO2) changes of single mouse cortical vessels in response to left forepaw electrical stimulation. Three difference levels of the cortical vessels (i.e., with different-sized diameters of 350, 100 and 55 μm) on activated regions were marked to measure their functional cross-section and SO2 changes as a function of time. Electrical stimulation of the mouse left forelimb was applied to evoke functional changes in vascular dynamics of the mouse somatosensory cortex. The applied current pulses were with a pulse frequency of 3 Hz, pulse duration of 0.2 ms, and pulse amplitude of 2 mA. The cerebrovascular cross-section changes, which indicate changes in cerebral blood volume (CBV), were probed by images acquired at 570 nm, a hemoglobin isosbestic point, while SO2 changes were monitored by the derivatives of 560-nm images normalized to 570-nm ones. The results show that vessel diameter and SO2 were significantly dilated and increased when compared with those of the controlled ones. In summary, the PAM shows its promise as a new imaging modality for transcranially functional quantification of single vessel diameter (i.e., CBV) and SO2 changes without any contrast agents applied during stimulation.
    Relation Link: http://spie.org/
    URI: http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/83954
    Appears in Collections:[電機工程學系] 會議論文
    [光電研究中心] 會議論文

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